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Chemical or biological agents which cause progenitor cells to differentiate into cartilage tissue lineage cells or which cause progenitor cells to differentiate into bone marrow stroma tissue lineage cells; pharmaceutical compositions, namely, mesenchymal stem cell (MSC) compositions for the regeneration of cardiac tissue and the treatment of heart disease; pharmaceutical compositions containing mesenchymal stem cells and their bone lineage committed descendants which may be combined with a matrix for bone repair and regeneration; cells for medical use for regeneration of human tissue, namely, bone, cartilage, marrow, muscle, adipose, tissue, and tendon composition; pharmaceutical composition containing mesenchymal stem cells which may be administered intravenously for immune response modulation and to affect tissue repair in treating immune and inflammatory disease