IONIS

Pharmaceutical preparations and substances, biological preparations and substances, therapeutic preparations and substances, namely, nucleic acid-targeted therapeutics; Pharmaceutical preparations and substances for the treatment of autosomal dominant, autosomal recessive, genetic, cardiovascular, neurologic, pulmonary, inflammatory, renal, metabolic, ophthalmologic, and rare diseases and disorders; Biological preparations and substances for the treatment of autosomal dominant, autosomal recessive, genetic, cardiovascular, neurologic, pulmonary, inflammatory, renal, metabolic, ophthalmologic, and rare diseases and disorders; Therapeutic preparations and substances for the treatment of autosomal dominant, autosomal recessive, genetic, cardiovascular, neurologic, pulmonary, inflammatory, renal, metabolic, ophthalmologic, and rare diseases and disorders