Active pharmaceutical ingredients (APIs), namely, oligonucleotide APIs for use in the manufacture of pharmaceuticals for treating tumor, asthma, arthritis, viral diseases, respiratory diseases, inflammation, fibrosis, hypertension, hyperlipidemia, cardiovascular diseases, eye diseases, angina, diabetes, and insomnia; active chemical ingredients for use in the manufacture of pharmaceuticals for treating tumor, asthma, arthritis, viral diseases, respiratory diseases, inflammation, fibrosis, hypertension, hyperlipidemia, cardiovascular diseases, eye diseases, angina, diabetes, and insomnia; biochemicals for in vitro and in vivo scientific use; diagnostic reagents and preparations, except for medical or veterinary use; biological preparation for use in cell cultures other than for medical or veterinary use; chemical preparations for scientific purposes, other than for medical or veterinary use; chemical reagents, other than for medical or veterinary purposes; chemical substances for analyses in laboratories, other than for medical or veterinary purposes; diagnostic preparations, other than for medical or veterinary purposes; reagent paper, other than for medical or veterinary purposes; test paper, chemical; biological preparations for use in industry and science.