THE SERVICE IS TO PROVIDE A STATISTICALLY ENTROPY-BASED NONPARAMETRIC TEST FOR VALIDATING SURROGATE ENDPOINTS BASED ON MEASURE OF DIVERGENCE AND RANDOM PERMUTATION (ARTICLE IS PUBLISHED IN STATISTICS IN MEDICINE, 2012). THIS TEST IS A PROPOSAL TO DIRECTLY VERIFY THE PRENTICE STATISTICAL DEFINITION OF SURROGACY. THE TEST DOES NOT IMPOSE DISTRIBUTIONAL ASSUMPTIONS ON THE ENDPOINTS AND IT IS ROBUST TO MODEL MISSPECIFICATION. THE SERVICE ALSO PROVIDES STATISTICAL ANALYSIS INCLUDING DATA MANAGEMENT AND SAS PROGRAMS FOR CLINICAL DATA, BIOMARKERS, AND SURROGATE ENDPOINTS.

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WANG, YONG-CHENG

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