COLNIQUE

Pharmaceuticals

Owner

SHIRE BIOCHEM INC.

COLMESA

Pharmaceuticals

Owner

SHIRE BIOCHEM INC.

COLONAX

Pharmaceuticals

Owner

SHIRE BIOCHEM INC.

MESAMAX

Pharmaceuticals

Owner

SHIRE BIOCHEM INC.

INNOVASA

Pharmaceuticals

Owner

SHIRE BIOCHEM INC.

COLNACT

Pharmaceuticals

Owner

SHIRE BIOCHEM INC.

COLVASA

Pharmaceuticals

Owner

SHIRE BIOCHEM INC.

ADVASA

Pharmaceuticals

Owner

SHIRE BIOCHEM INC.

COLVAST

Pharmaceuticals

Owner

SHIRE BIOCHEM INC.

LIFE IS OUR BUSINESS

Pharmaceuticals and 5 others

Owner

SHIRE BIOCHEM INC.

SHIRE BIOLOGICS

Pharmaceuticals and 2 other

Owner

SHIRE BIOCHEM INC.

AXIOS

Pharmaceuticals

Owner

SHIRE BIOCHEM INC.

VIVEDIL

Pharmaceuticals

Owner

SHIRE BIOCHEM INC.

CADX MEDICAL SYSTEMS

Medical Apparatus

Owner

SHIRE BIOCHEM INC.

Jul 29, 2003